Purpose: Androgen Deprivation Therapy (ADT) leads to physical impairment and frailty in older men with Prostate Cancer (PC). In older men on ADT, there are no randomized controlled studies of physical activity interventions in older adults. Furthermore, no studies have assessed the use of Nintendo's Wii fit device for improving physical performance in older adults with cancer. We tested the feasibility and efficacy of either a tailored, multi-component exercise intervention of either a home-based exercise program (EXCAP) or a home-based computer-generated exercise program for PC patients utilizing Nintendo's Wii fit technology (Wii) for older men on ADT.