A Time to Event Tutorial for Pharmacometricians

Models for time to event provide the link between standard pharmacokinetic–dynamic models disease progression, and clinical outcome events. The biological basis for events may be expressed quantitatively in terms of a hazard function. This tutorial explains hazards and how doses can be linked to events predicted from hazard functions. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e43; doi: 10.1038/psp.2013.18 ; advance online publication 15 May 2013