Assessment of perihematomal hypoperfusion injury in subacute and chronic intracerebral hemorrhage by CT perfusion imaging

血肿 灌注 医学 脑血流 脑出血 灌注扫描 血容量 核医学 放射科 心脏病学 麻醉 格拉斯哥昏迷指数
作者
Jian Zhou,Hongmei Zhang,Peiyi Gao,Yan Lin,Xiaoguang Li
出处
期刊:Neurological Research [Informa]
卷期号:32 (6): 642-649 被引量:13
标识
DOI:10.1179/016164109x12445616596328
摘要

To study alterations of perihematomal cerebral perfusion associated to subacute and chronic intracerebral hemorrhage (ICH) by means of computed tomography perfusion (CTP) imaging.Non-enhanced CT scan and CTP examination were performed in 12 patients with subacute and chronic supratentorial ICH. The hematoma volume was measured, and the regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP) adjacent to hematoma were measured in 11 of 12 cases.Eleven patients with mean age of 58.1 years were finally analysed. Mean time interval from symptom onset to initial CTP scanning was 18.4 days; mean hematoma volume was 26.8 ml. The gradient of hypoperfusion around the hematoma was revealed by rCBF maps in 11 cases, and by rCBV maps in ten cases. The areas of delayed TTP and MTT were showed in 11 and ten cases, respectively. The degree of reduction in rCBV correlated strongly with the hematoma volume (r(inner)=0.764, p=0.006;r(outer)=0.703, p=0.016). There was no correlation between the changes in rCBF, rCBV, MTT and TTP and the time interval from symptom onset to initial CTP examination.We have concluded that the gradient of hypoperfusion surrounding the hematoma may still exist during the subacute and chronic phases after ICH. The alterations in rCBV correlate with the hematoma volume. We believe that the reperfusion injury marked by increased rCBV contributes to the perilesional brain injury. The quantitative CT perfusion measurements can provide valuable information in individual management and prognostic evaluation of ICH.
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