异三聚体G蛋白
G蛋白
内吞作用
细胞生物学
G蛋白偶联受体
受体
蛋白质靶向
信号转导
5-HT5A受体
阿片受体
生物
转运蛋白
化学
膜蛋白
生物化学
类阿片
膜
作者
Jennifer L. Whistler,Johan Enquist,Aaron Marley,Jamie Fong,Fredrik Gladher,Pamela R. Tsuruda,Stephen R. Murray,Mark von Zastrow
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2002-07-26
卷期号:297 (5581): 615-620
被引量:315
标识
DOI:10.1126/science.1073308
摘要
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensitization of signal transduction, whereas targeting of the delta opioid receptor (DOR) to lysosomes causes proteolytic down-regulation. We identified a protein that binds preferentially to the cytoplasmic tail of the DOR as a candidate heterotrimeric GTP-binding protein (G protein)–coupled receptor-associated sorting protein (GASP). Disruption of the DOR-GASP interaction through receptor mutation or overexpression of a dominant negative fragment of GASP inhibited receptor trafficking to lysosomes and promoted recycling. The GASP family of proteins may modulate lysosomal sorting and functional down-regulation of a variety of G protein–coupled receptors.
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