A Novel Diagnostic Method for Acute Pulmonary Embolism: Technetium-99m Apcitide Scintigraphy

Letters1 June 2004A Novel Diagnostic Method for Acute Pulmonary Embolism: Technetium-99m Apcitide ScintigraphyJonathan M. Davison, MD, Robert Bridwell, MD, MBA, Jamie L. Montilla, MD, Edward Jackson, MD, and Lisa K. Moores, MDJonathan M. Davison, MDFrom Walter Reed Army Medical Center, Washington, DC 20307-5001., Robert Bridwell, MD, MBAFrom Walter Reed Army Medical Center, Washington, DC 20307-5001., Jamie L. Montilla, MDFrom Walter Reed Army Medical Center, Washington, DC 20307-5001., Edward Jackson, MDFrom Walter Reed Army Medical Center, Washington, DC 20307-5001., and Lisa K. Moores, MDFrom Walter Reed Army Medical Center, Washington, DC 20307-5001.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-11-200406010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editor's Note:The lead author of the following Clinical Observation was one of a dozen Associates of the American College of Physicians selected to present a clinical vignette at the 2002 Annual Session in Philadelphia. We are proud to present this case report through a special arrangement with the Council of Associates of the College.TO THE EDITOR:Background: Pulmonary embolism is one of the leading causes of morbidity and death in the United States, with a purported 500 000 to 600 000 cases and an estimated 50 000 to 200 000 deaths occurring per year (1). The currently accepted diagnostic algorithm is integrated and ...References1. Taillefer R, Edell S, Innes G, Lister-James J. Acute thromboscintigraphy with (99m)Tc-apcitide: results of the phase 3 multicenter clinical trial comparing 99mTc-apcitide scintigraphy with contrast venography for imaging acute DVT. Multicenter Trial Investigators. J Nucl Med. 2000;41:1214-23. [PMID: 10914912] MedlineGoogle Scholar2. Goldhaber SZ. Pulmonary embolism. N Engl J Med. 1998;339:93-104. [PMID: 9654541] CrossrefMedlineGoogle Scholar3. Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, et al . Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost. 2000;83:416-20. [PMID: 10744147] CrossrefMedlineGoogle Scholar4. Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, et al . Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997-1005. [PMID: 9867786] LinkGoogle Scholar5. Sandler MP, Coleman RE, Patton JA, Wackers FJ, Gottschalk A. Diagnostic Nuclear Medicine. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2003. Google Scholar6. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED Investigators. JAMA. 1990;263:2753-9. [PMID: 2332918] CrossrefMedlineGoogle Scholar7. van Strijen MJ, de Monye W, Schiereck J, Kieft GJ, Prins MH, Huisman MV, et al . Single-detector helical computed tomography as the primary diagnostic test in suspected pulmonary embolism: a multicenter clinical management study of 510 patients. Ann Intern Med. 2003;138:307-14. [PMID: 12585828] LinkGoogle Scholar8. Taillefer R, Therasse E, Turpin S, Lambert R, Robillard P, Soulez G. Comparison of early and delayed scintigraphy with 99mTc-apcitide and correlation with contrast-enhanced venography in detection of acute deep vein thrombosis. J Nucl Med. 1999;40:2029-35. [PMID: 10616882] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Walter Reed Army Medical Center, Washington, DC 20307-5001. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUse of a Clinical Model for Safe Management of Patients with Suspected Pulmonary Embolism Philip S. Wells , Jeffrey S. Ginsberg , David R. Anderson , Clive Kearon , Michael Gent , Alexander G. Turpie , Janis Bormanis , Jeffrey Weitz , Michael Chamberlain , Dennis Bowie , David Barnes , and Jack Hirsh Single-Detector Helical Computed Tomography as the Primary Diagnostic Test in Suspected Pulmonary Embolism: A Multicenter Clinical Management Study of 510 Patients Marco J.L. van Strijen , Wouter de Mony , Jan Schiereck , Gerard J. Kieft , Martin H. Prins , Menno V. Huisman , Peter M.T. Pattynama , and Metrics Cited ByMaladie veineuse thrombo-embolique – Session 2SPECT Imaging of Pulmonary Emboli with Radiolabeled Thrombus-Specific Imaging Agents99mTc-apcitide scintigraphy in patients with clinically suspected deep venous thrombosis and pulmonary embolismThe Current and Continuing Important Role of Ventilation-Perfusion Scintigraphy in Evaluating Patients With Suspected Pulmonary EmbolismMolecular Imaging of Cardiovascular Disease 1 June 2004Volume 140, Issue 11Page: 936-939KeywordsAllergy and immunologyComputed axial tomographyGlycoproteinsLikelihood ratioLungsPlateletsPulmonary embolismRadionuclide imagingThoraxThrombosis ePublished: 1 June 2004 Issue Published: 1 June 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...