Estrogen Receptor Genotypes and Their Association with the 10-Year Changes in Bone Mineral Density and Osteocalcin Concentrations

We conducted a 10-yr prospective study of peak bone mass and its change in 604 women, aged 24–44 yr at study initiation, and related changes in bone mineral density (BMD) and osteocalcin (OCN) concentrations to estrogen receptor (ER) α gene polymorphisms in 442 of these women.