Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper‐Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes

Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism in which a CO bond is formed by the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition.