生物
发育生物学
转录组
秀丽隐杆线虫
基因
发展里程碑
隐杆线虫病
胚胎
发育阶段
进化生物学
遗传学
进化发育生物学
基因表达
细胞生物学
心理学
发展心理学
作者
Michael Levin,Tamar Hashimshony,Florian Wagner,Itai Yanai
标识
DOI:10.1016/j.devcel.2012.04.004
摘要
A fundamental question in developmental biology relates to the connection between morphological stages and their underlying molecular activity. Here we demonstrate that, at the molecular level, embryonic development in five Caenorhabditis species proceeds through two distinct milestones in which the transcriptome is resistant to differences in species-specific developmental timings. By comparing the complete protein-coding transcriptomes of individually timed embryos across ten morphological markers, we found that developmental milestones can be characterized by their expression dynamics and activation of key developmental regulators. This approach led us to discover the nematode phylotypic stage and to show that in chordates and arthropods it is represented as two distinct stages, suggesting that animal body plans might evolve by uncoupling and elaboration on formerly synchronous processes.
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