化学
香豆素
水杨醛
串联
芳基
烯烃
杂原子
组合化学
过渡金属
级联反应
自由基
有机化学
催化作用
立体化学
烷基
席夫碱
材料科学
复合材料
盐(化学)
作者
Jianming Liu,Xin Zhang,Lijun Shi,Muwen Liu,Yuanyuan Yue,Fuwei Li,Kelei Zhuo
摘要
Facile synthesis of coumarin via the tandem reaction of salicylaldehyde with aryl-substituted 1,1-dibromo-1-alkene was developed. This new protocol proceeds smoothly under mild and transition-metal-free conditions, it allows rapid access to coumarins containing various heteroatoms that are more difficult to prepare by traditional methods. Based on the isolated intermediate of 4-(diethylamino)-3-phenylchroman-2-one and detailed mechanistic studies, a credible tandem pathway was proposed.
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