神经保护
雌激素
兴奋毒性
氧化应激
雌激素受体
药理学
神经科学
神经退行性变
医学
生物
内科学
疾病
受体
谷氨酸受体
癌症
乳腺癌
作者
Pattie S. Green,James W. Simpkins
标识
DOI:10.1016/s0736-5748(00)00017-4
摘要
Abstract Epidemiological studies associate post‐menopausal estrogen use with a reduction in risk of Alzheimer's disease, a reduction in risk of Parkinson's disease, and death from stroke. The neuroprotective efficacy of estrogens have been well described and may contribute to these clinical effects. Estrogen‐mediated neuroprotection has been described in several neuronal culture model systems with toxicities including serum‐deprivation, β‐amyloid‐induced toxicity, excitotoxicity, and oxidative stress. In animal models, estrogens have been shown to attenuate neuronal death in rodent models of cerebral ischemia, traumatic injury, and Parkinson's disease. Although estrogens are known to exert several direct effects on neurons, the cellular mechanisms behind the neuroprotective efficacy of the steroid are only beginning to be elucidated. In this review, we summarize the data supporting a neuroprotective role for estrogens in both culture and animal models and discuss neuronal effects of estrogens that may contribute to the neuroprotective effects. These effects include activation of the nuclear estrogen receptor, altered expression of bcl‐2 and related proteins, activation of the mitogen activated kinase pathway, activation of cAMP signal transduction pathways, modulation of intracellular calcium homeostasis, and direct antioxidant activity.
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