胆碱能神经元
胆碱能的
基底前脑
神经科学
阿尔茨海默病
淀粉样蛋白(真菌学)
神经营养素
神经营养因子
医学
疾病
生物
病理
内科学
受体
作者
Rebecca M. Burke,Timothy A. Norman,Tarik F. Haydar,Barbara E. Slack,Susan E. Leeman,Jan Krzysztof Blusztajn,Tiffany J. Mellott
标识
DOI:10.1073/pnas.1319297110
摘要
Significance Bone morphogenetic protein 9 (BMP9) is a trophic factor for basal forebrain cholinergic neurons (BFCN) and constitutes a candidate therapeutic molecule for diseases characterized by BFCN dysfunction. A prominent example of such an illness, for which effective therapies are critically needed, is Alzheimer’s disease (AD). A decline in BFCN function and diminished cholinergic marker expression occurs in brains of patients with AD and is observed in AD animal models. We report that BMP9 administration is effective in reducing the amyloid plaque burden, reversing cholinergic neuron abnormalities, and generating a neurotrophic milieu for cholinergic neurons in a mouse model of AD, thus providing evidence that the BMP9-signaling pathway may constitute a novel therapeutic target in AD.
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