医学
甲状腺
组织病理学
入射(几何)
腮腺
病理
内科学
光学
物理
作者
Joseph E. Russ,Edward F. Scanlon,Stephen Sener
出处
期刊:Cancer
[Wiley]
日期:1979-03-01
卷期号:43 (3): 1078-1083
被引量:52
标识
DOI:10.1002/1097-0142(197903)43:3<1078::aid-cncr2820430344>3.0.co;2-r
摘要
Parathyroid adenomas have been demonstrated to occur following external head and neck irradiation. The median latency interval is 30 years. In a series of 74 consecutive patients with histologically diagnosed parathyroid adenomas, 25% gave a history of prior radiation exposure. When compared to a matched control incidence of 7.9%, statistical significance is reached at p < 0.01. Thyroid abnormalities were present in 68% of the irradiated patients, and 30% of these were malignant. Tumors of skin, breast, and parotid gland also occurred more frequently than expected. Forty-seven percent of the irradiated group had malignant neoplasms within the radiation field. The histopathology of the radiation-associated parathyroid adenomas is similar to that seen experimentally. Cancer 43:1078–1083, 1979.
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