青光眼
轴突
视网膜
神经科学
高眼压
视网膜神经节细胞
视神经
变性(医学)
眼压
眼科
神经节
医学
轴浆运输
视网膜
生物
作者
Marta Agudo‐Barriuso,M.P. Villegas–Pérez,J Miralles de Imperial,Manuel Vidal‐Sanz
标识
DOI:10.1016/j.coph.2012.09.006
摘要
Glaucoma is a progressive neurodegenerative disease caused by retinal ganglion cell (RGC) loss. One important risk factor for glaucoma is elevated intraocular pressure and thus many animal models are based on spontaneous or induced ocular hypertension (OHT). Using these models it has been shown that RGCs initially suffer an impairment of the active axonal transport that progresses to a lack of passive diffusion along the axon. This axonal damage eventually causes the death of the parent RGCs in pie-shaped sectors of the retina, but there is also diffuse RGC loss, without involving displaced amacrine cells. Recent data show that OHT results in a protracted insult to the inner and outer retina that causes functional alterations and ultimately, degeneration and death of cones.
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