亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Peripheral Neuropathies of Rheumatologic Disease and Gluten-Related Disorders

医学 周围神经病变 外周神经系统 疾病 免疫抑制 外围设备 内科学 中枢神经系统 糖尿病 内分泌学
作者
Russell L. Chin,Haatem Reda
出处
期刊:Seminars in Neurology [Georg Thieme Verlag KG]
卷期号:34 (04): 413-424 被引量:15
标识
DOI:10.1055/s-0034-1390390
摘要

Peripheral nervous system disease is a common and often debilitating feature of many systemic rheumatologic disorders. Such involvement takes many forms, reflecting the variety of underlying pathophysiology, though most patients present with painful multifocal neuropathy (usually vasculitic) or a distal sensory more than motor peripheral neuropathy (sometimes vasculitic and nearly always axonal). The presence of peripheral nervous system involvement is often an early signal of the generalization of inflammatory disease in blood vessels or extravascular tissues, though peripheral neuropathy is not itself an independent predictor of mortality. Nonetheless, progressive multifocal neuropathy, motor neuropathy, small fiber neuropathy, and sensory neuronopathy should be treated early and aggressively with immunosuppression (or the gluten-free diet in appropriate situations) to limit morbidity. Given the rapidly evolving therapeutic landscape, partnership with a rheumatologist is essential. Treatment is usually sustained for 1 to 2 years, and remission is possible in many cases within 6 to 12 months, with variable rates of relapse and treatment resistance. Patients should be meticulously monitored for relapse with serial laboratory testing, electrodiagnostic studies, and clinical examination. Functional rating scores, such as the neuropathy impairment scale and the total neuropathy score are useful for longitudinal assessment.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
booker完成签到 ,获得积分10
1秒前
2秒前
5秒前
6秒前
8秒前
vincen91发布了新的文献求助10
9秒前
11秒前
supermaltose发布了新的文献求助10
13秒前
15秒前
红红酱发布了新的文献求助10
23秒前
30秒前
supermaltose完成签到,获得积分10
30秒前
Hayat应助科研通管家采纳,获得10
37秒前
FashionBoy应助spearbog采纳,获得10
48秒前
1分钟前
1分钟前
1分钟前
1分钟前
拓跋从阳发布了新的文献求助10
1分钟前
嗯哼应助铮铮铁骨采纳,获得10
1分钟前
1分钟前
zxx0126发布了新的文献求助10
1分钟前
1分钟前
胡林完成签到 ,获得积分0
1分钟前
1分钟前
阿玉完成签到 ,获得积分20
1分钟前
铮铮铁骨发布了新的文献求助10
2分钟前
2分钟前
ww发布了新的文献求助10
2分钟前
嗯哼应助铮铮铁骨采纳,获得10
2分钟前
2分钟前
zyq111111发布了新的文献求助10
2分钟前
邓力应助科研通管家采纳,获得10
2分钟前
Hayat应助科研通管家采纳,获得10
2分钟前
顾矜应助科研通管家采纳,获得10
2分钟前
yeyi9851应助科研通管家采纳,获得10
2分钟前
2分钟前
2分钟前
zyq111111完成签到,获得积分10
2分钟前
3分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
New China Forges Ahead: Important Documents of the Third Session of the First National Committee of the Chinese People's Political Consultative Conference 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056448
求助须知:如何正确求助?哪些是违规求助? 2713056
关于积分的说明 7434445
捐赠科研通 2358100
什么是DOI,文献DOI怎么找? 1249233
科研通“疑难数据库(出版商)”最低求助积分说明 606992
版权声明 596195