Peripheral Neuropathies of Rheumatologic Disease and Gluten-Related Disorders

医学 周围神经病变 外周神经系统 疾病 免疫抑制 外围设备 内科学 中枢神经系统 糖尿病 内分泌学
作者
Russell L. Chin,Haatem Reda
出处
期刊:Seminars in Neurology [Georg Thieme Verlag KG]
卷期号:34 (04): 413-424 被引量:15
标识
DOI:10.1055/s-0034-1390390
摘要

Peripheral nervous system disease is a common and often debilitating feature of many systemic rheumatologic disorders. Such involvement takes many forms, reflecting the variety of underlying pathophysiology, though most patients present with painful multifocal neuropathy (usually vasculitic) or a distal sensory more than motor peripheral neuropathy (sometimes vasculitic and nearly always axonal). The presence of peripheral nervous system involvement is often an early signal of the generalization of inflammatory disease in blood vessels or extravascular tissues, though peripheral neuropathy is not itself an independent predictor of mortality. Nonetheless, progressive multifocal neuropathy, motor neuropathy, small fiber neuropathy, and sensory neuronopathy should be treated early and aggressively with immunosuppression (or the gluten-free diet in appropriate situations) to limit morbidity. Given the rapidly evolving therapeutic landscape, partnership with a rheumatologist is essential. Treatment is usually sustained for 1 to 2 years, and remission is possible in many cases within 6 to 12 months, with variable rates of relapse and treatment resistance. Patients should be meticulously monitored for relapse with serial laboratory testing, electrodiagnostic studies, and clinical examination. Functional rating scores, such as the neuropathy impairment scale and the total neuropathy score are useful for longitudinal assessment.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助weirdo采纳,获得10
1秒前
zoe666发布了新的文献求助30
4秒前
Ethan完成签到,获得积分10
5秒前
科研通AI2S应助www采纳,获得10
5秒前
子车茗应助www采纳,获得10
5秒前
6秒前
6秒前
鲤鱼完成签到,获得积分10
7秒前
ai阅读的初学者完成签到,获得积分10
9秒前
情怀应助美满的涔采纳,获得10
9秒前
良辰应助yiseeya采纳,获得10
11秒前
华仔应助郑麻采纳,获得10
12秒前
www完成签到,获得积分20
14秒前
哈哈发布了新的文献求助10
14秒前
阳光总在风雨后完成签到,获得积分10
15秒前
InfoNinja应助嘘唏采纳,获得30
15秒前
曹帅发布了新的文献求助10
15秒前
11应助feiyu采纳,获得20
16秒前
16秒前
王二完成签到,获得积分10
18秒前
今后应助1DDDDD采纳,获得10
18秒前
zshjwk18完成签到,获得积分10
18秒前
20秒前
20秒前
传奇3应助科研通管家采纳,获得10
21秒前
Akim应助科研通管家采纳,获得10
21秒前
我是老大应助科研通管家采纳,获得10
21秒前
wanci应助科研通管家采纳,获得30
21秒前
上官若男应助科研通管家采纳,获得10
21秒前
21秒前
甜甜玫瑰应助科研通管家采纳,获得10
21秒前
今后应助科研通管家采纳,获得10
21秒前
丘比特应助科研通管家采纳,获得10
21秒前
葡萄成熟应助科研通管家采纳,获得10
21秒前
pluto应助科研通管家采纳,获得10
22秒前
22秒前
22秒前
22秒前
23秒前
舒心新儿发布了新的文献求助10
24秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3138888
求助须知:如何正确求助?哪些是违规求助? 2789815
关于积分的说明 7792820
捐赠科研通 2446185
什么是DOI,文献DOI怎么找? 1300930
科研通“疑难数据库(出版商)”最低求助积分说明 626066
版权声明 601079