ROLE OF HELICOBACTER PYLORI IN DIABETES MELLITUS & ITS COMPLICATIONS

Introduction: Human being are major reservoir of Helicobacter pylori (H.pylori).The organism has been associated with gastritis, peptic ulcer, gastric cancer and many other nongastrointestinal tract diseases.This study aimed at detection and comparison of anti H. pylori antibodies (IgG) in serum of diabetes mellitus and non-diabetic cases as well as to observe the relationship of anti H. pylori antibodies to complications of diabetes mellitus.MATERIALS AND METHODS: The study group included 101 diabetics, diagnosed as per standard criteria.Of the total, 91 were type 2 and 10 were type 1 diabetes mellitus cases.The control group included 30 nos. of age and sex matched healthy subjects.Demographic and clinical information of both groups were recorded.RESULTS: Anti H. pylori antibodies (IgG) were found 88.1% in diabetics and 70% in control group and the result was significant statistically (P<0.05).The most common manifestation in anti H. pylori antibodies positive cases pyrosis (58.4%) followed by nausea (39%).High positivity of anti H. pylori antibodies were observed in almost all age groups in the diabetic group than the control.However, statistical significant difference was seen only in two age groups.CONCLUSION: The result showed that diabetics are more prone to H. pylori infection and need continuous monitoring.