Benefit from Alternate-Day Prednisone in Myasthenia Gravis

Five adults with myasthenia gravis of varying severity and duration were treated with long-term, high-single-dosage (100 mg), alternate-day oral prednisone. Improvement in muscle function appeared 24 to 72 hours after the initiation of therapy and has been maintained from six to 17 months. Complete remission of symptoms was obtained in one patient in four months and has been maintained for 13 months.