Sol-gel method has been more and more comprehensively used in preparations of catalysts.The mechanisms,classification and application of sol-gel method were reviewed,including influences of metal precursors,hydrolysis,drying and calcinations temperature on preparation of catalysts with high dispersion,high surface area and good pore distribution were discussed.It was shown that isopropane oxidation catalyst prepared by sol-gel method had improved active components dispersion and lattice oxygen species,with enhanced isopropane conversion and selectivity to target product.