Socioeconomic Deprivation Index Is Associated With Psychiatric Disorders: An Observational and Genome-wide Gene-by-Environment Interaction Analysis in the UK Biobank Cohort

队列 精神科 医学 萧条(经济学) 双相情感障碍 焦虑 重性抑郁障碍 生命银行 队列研究 优势比 内科学 生物信息学 心情 生物 宏观经济学 经济
作者
Jing Ye,Yan Wen,Xifang Sun,Xiaomeng Chu,Ping Li,Bolun Cheng,Shiqiang Cheng,Li Liu,Lu Zhang,Mei Ma,Xin Qi,Chujun Liang,Om Prakash Kafle,Yumeng Jia,Cuiyan Wu,Sen Wang,Xi Wang,Yujie Ning,Shiquan Sun,Feng Zhang
出处
期刊:Biological Psychiatry [Elsevier BV]
卷期号:89 (9): 888-895 被引量:86
标识
DOI:10.1016/j.biopsych.2020.11.019
摘要

Background Psychiatric disorders are among the largest and fastest-growing categories of the global disease burden. However, limited effort has been made to further elucidate associations between socioeconomic factors and psychiatric disorders from a genetic perspective. Methods We randomly divided 501,882 participants in the UK Biobank cohort with socioeconomic Townsend deprivation index (TDI) data into a discovery cohort and a replication cohort. For both cohorts, we first conducted regression analyses to evaluate the associations between the TDI and common psychiatric disorders or traits, including anxiety, bipolar disorder, self-harm, and depression (based on self-reported depression and Patient Health Questionnaire scores). We then performed a genome-wide gene-by-environment interaction study using PLINK 2.0 with the TDI as an environmental factor to explore interaction effects. Results In the discovery cohort, significant associations were observed between the TDI and psychiatric disorders (p < 4.00 × 10−16), including anxiety (odds ratio [OR] = 1.08, 95% confidence interval [CI] = 1.07–1.10), bipolar disorder (OR = 1.42, 95% CI = 1.36–1.48), self-harm (OR = 1.21, 95% CI = 1.19–1.23), self-reported depression (OR = 1.22, 95% CI = 1.20–1.24), and Patient Health Questionnaire scores (β = .07, SE = 0.004). We observed similar significant associations in the replication cohort. In addition, multiple candidate loci were identified by the genome-wide gene-by-environment interaction study, including rs10886438 at 10q26.11 (GRK5) (p = 5.72 × 10−11) for Patient Health Questionnaire scores and rs162553 at 2p22.2 (CYP1B1) (p = 2.25 × 10−9) for self-harm. Conclusions Our findings suggest the relevance of the TDI to psychiatric disorders. The genome-wide gene-by-environment interaction study identified several candidate genes interacting with the TDI, providing novel clues for understanding the biological mechanism of associations between the TDI and psychiatric disorders.
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