Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

医学 特应性皮炎 生活质量(医疗保健) 斯科拉德 荟萃分析 皮肤科生活质量指数 梅德林 心理干预 斯科普斯 疾病 系统回顾 疾病严重程度 物理疗法 老年学 内科学 皮肤病科 精神科 法学 护理部 政治学
作者
Gurkiran Birdi,Richard Cooke,Rebecca Knibb
出处
期刊:International Journal of Dermatology [Wiley]
卷期号:59 (4) 被引量:51
标识
DOI:10.1111/ijd.14763
摘要

Abstract Atopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults . A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles published until October 2018. Inclusion criteria were a clinical diagnosis of AD, adult patients, and QoL as an outcome measure. Interventions were excluded. A total of 32 studies were included. While QoL was assessed using Dermatology Life Quality Index (DLQI) in 25 studies, there was heterogeneity in the tools used to measure disease severity across studies. Meta‐analysis of the seven studies that used the SCORAD to measure disease severity showed severity to be significantly related to poorer QoL. The remaining 18 studies also showed increased disease severity significantly related to poorer QoL. When compared to healthy controls, AD patients demonstrated significantly lower QoL, but findings were mixed in studies that compared QoL in AD to other skin conditions. The findings highlight the significant impact that AD has on QoL in adults and the need for validated and relevant QoL measures to be implemented in clinical assessments for AD. Areas that require further research include an exploration of gender differences in QoL and the use of longitudinal study designs to explore factors that may cause differences in QoL ratings.
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