合生元
脂多糖
肠道菌群
移植
医学
肝性脑病
粪便细菌疗法
肠-脑轴
粪便
生物
失调
炎症
免疫学
败血症
免疫系统
内科学
微生物学
益生菌
细菌
抗生素
艰难梭菌
肝硬化
遗传学
作者
Suyan Li,Hui Guo,Xin Xu,Ranliang Hua,Qian Zhao,Jian Li,Jian Lv,Jianguo Li
出处
期刊:Shock
[Ovid Technologies (Wolters Kluwer)]
日期:2021-02-15
卷期号:56 (5): 824-831
被引量:7
标识
DOI:10.1097/shk.0000000000001758
摘要
To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.Rats were treated with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics after exposure to lipopolysaccharide. The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats. More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats. These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
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