肌萎缩侧索硬化
肌酐
医学
内科学
肾功能
人口
比例危险模型
呼吸系统
心脏病学
疾病
环境卫生
作者
João Morgadinho,Ana Catarina Pronto‐Laborinho,Vasco A. Conceição,Marta Gromicho,Susana Pinto,Michael Swash,Mamede de Carvalho
出处
期刊:Journal of neuromuscular diseases
[IOS Press]
日期:2021-02-23
卷期号:8 (5): 795-799
被引量:4
摘要
In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It has not been clear if creatinine is associated with respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression and Cox-regression analyses were performed. We included 233 patients, mean age 62.8, mean disease duration of 18.6 months. At baseline, creatinine was significantly associated with ALSFRS-R, but not with its decline rate. No predictive value was disclosed for FVC, its decline rate, or with survival. We did not confirm that creatinine is a marker of respiratory outcome.
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