再生(生物学)
神经导管
周围神经
3d打印
神经外膜修复
周围神经损伤
再生医学
外围设备
组织工程
电气导管
血管网
解剖
神经科学
医学
生物医学工程
计算机科学
细胞生物学
生物
干细胞
内科学
电信
作者
Jie Tao,Yan He,Shuai Wang,Jian Mao
标识
DOI:10.1016/j.mehy.2019.109395
摘要
Peripheral nerve regeneration remains a challenge in tissue engineering and regenerative medicine. However, the existing approaches have limited regenerative capability. 3D-printed nerve conduits with well-defined properties are potent tools to facilitate peripheral nerve regeneration after injuries. Meanwhile, the vascular networks within the constructs can promote the exchange of oxygen, neurotrophic factors, and removal of waste products, thereby providing an advantageous microenvironment for tissue regeneration. It will be an interesting approach to integrate 3D-printed nerve conduit with vascular networks for the guidance of regenerated nerves. We hypothesize that 3D-printed vascularized nerve conduit will be an effective platform to promote nerve regeneration and functional restoration.
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