上睑下垂
炎症体
吡喃结构域
NLRC4型
目标2
半胱氨酸蛋白酶1
细胞生物学
生物
炎症
癌症研究
免疫学
作者
Yansong Xue,Daniel Enosi Tuipulotu,Tan Wang,Callum Kay,Si Ming Man
标识
DOI:10.1016/j.it.2019.09.005
摘要
The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer. Studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including NLRP1b, NLRP3, NOD-like receptor family apoptosis inhibitory protein (NAIP)-NLRC4, absent in melanoma (AIM)2, caspase-11, and pyrin. New activators and regulators of emerging NLRP6 and NLRP9b inflammasome complexes have also been described. We highlight the latest progress in our understanding of the molecular mechanisms governing inflammasome activation and pyroptosis, including the discovery of the pore-forming protein gasdermin D (GSDMD). We also discuss the importance of inflammasome activators and regulators in health and disease.
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