With the continuous improvement of manufacturing automation in China, traditional processing methods have been unable to meet the needs of social development. Advanced industrial robots have gradually replaced manual operation and are applied in various fields of manufacturing industry. In this paper, the robot Studio software developed by ABB company is used for manual off-line programming and virtual simulation design of ABB welding robot. It is of great significance to build a virtual simulation system of robot welding operation through the off-line programming software of robot studio, reasonably plan and configure production resources, shorten the development cycle of production line, save operation time and improve work efficiency.