通风(建筑)
医学
肺活量测定
电阻抗断层成像
潮气量
肺活量
慢性阻塞性肺病
肺功能测试
肺容积
心脏病学
麻醉
呼吸系统
肺
内科学
放射科
肺功能
断层摄影术
扩散能力
气象学
哮喘
物理
作者
Livia Lasarow,B Vogt,Zhanqi Zhao,Lorenz Balke,Norbert Weiler,Inéz Frerichs
出处
期刊:Physiological Measurement
[IOP Publishing]
日期:2021-01-01
卷期号:42 (1): 015008-015008
被引量:23
标识
DOI:10.1088/1361-6579/abdad6
摘要
Abstract Objective. Current standards for conducting spirometry examinations recommend that the ventilation manoeuvres needed in pulmonary function testing are carried out repeatedly during sessions. Chest electrical impedance tomography (EIT) can determine the presence of ventilation heterogeneity during such manoeuvres, which increases the information content derived from such examinations. The aim of this study was to characterise regional lung function in patients with chronic obstructive pulmonary disease (COPD) during repetitive forced full ventilation manoeuvres. Regional lung function measures derived from these manoeuvres were compared with quiet tidal breathing. Approach . Sixty hospitalised patients were examined during up to three repeated ventilation manoeuvres. Acceptable spirometry manoeuvres were performed and EIT recordings suitable for analysis obtained in 53 patients (12 women, 41 men; age: 68 ± 12 years (mean ± SD)). Pixel values of tidal volume, forced full inspiratory and expiratory volume in 1 s, and forced inspiratory and expiratory vital capacity were calculated from the EIT data. Spatial ventilation heterogeneity was assessed using the coefficient of variation, global inhomogeneity index, and centres and regional fractions of ventilation. Temporal inhomogeneity was determined by examining the pixel expiration times needed to exhale 50% and 75% of regional forced vital capacity. Main results . All EIT-derived measures of regional lung function showed reproducible results during repetitive examinations. Parameters of spatial heterogeneity obtained from quiet tidal breathing were comparable with the measures derived from the forced manoeuvres. Significance . Measures of spatial and temporal ventilation heterogeneity obtained in COPD patients by EIT provide comparable findings during repeated examinations within one testing session. Quiet tidal breathing generates similar information on ventilation heterogeneity as forced manoeuvres that demand a high amount of patient effort.
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