自愈水凝胶
纳米颗粒
自愈
壳聚糖
聚合物
药物输送
挤压
组织工程
化学工程
生物医学工程
材料科学
氧化铁纳米粒子
纳米技术
复合材料
高分子化学
工程类
替代医学
病理
医学
作者
Eun Seok Ko,Choonggu Kim,Youngtae Choi,Kuen Yong Lee
标识
DOI:10.1016/j.carbpol.2020.116496
摘要
Hydrogel systems that show self-healing ability after mechanical damage are receiving increasing attention. However, self-healing hydrogels suitable for biomedical applications are limited owing to complex preparation methods. Furthermore, few studies have demonstrated the self-healing property of ferrogels. In this study, we demonstrated that glycol chitosan (GC) and oxidized hyaluronate (OHA) can be used to form a self-healing ferrogel in the presence of superparamagnetic iron oxide nanoparticles (SPIONs) without additional chemical cross-linkers. The overall characteristics of GC/OHA/SPION ferrogel varied based on the GC/OHA ratio, SPION content, and total polymer concentration. Interestingly, GC/OHA/SPION ferrogel was used to fabricate 3D-printed constructs of various shapes via an extrusion printing method. These constructs were responsive to the magnetic field, suggesting their potential application in 4D printing. This approach to developing self-healing ferrogels with biocompatible polysaccharides may prove useful in designing and fabricating drug delivery systems and tissue engineering scaffolds, via 3D printing.
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