Effect of intraoperative mitomycin-C application on epithelial regeneration after transepithelial photorefractive keratectomy

医学 光折变性角膜切除术 丝裂霉素C 视力 眼科 外科 入射(几何) 前瞻性队列研究 眼病 光学 物理
作者
Nan‐Ji Lu,Carina Koppen,Shady T. Awwad,Minas I. Aslanides,Ioannis M. Aslanides,Shihao Chen
出处
期刊:Journal of Cataract and Refractive Surgery [Lippincott Williams & Wilkins]
卷期号:47 (2): 227-232 被引量:4
标识
DOI:10.1097/j.jcrs.0000000000000427
摘要

To investigate the effect of mitomycin-C (MMC) intraoperative application on postoperative corneal epithelial remodeling, haze incidence, and refractive correction in transepithelial photorefractive keratectomy (transPRK).Eye Hospital of Wenzhou Medical University, Wenzhou, China.Prospective randomized controlled study.Eyes that completed all follow-ups were included. Epithelial thickness (ET) map measurement was conducted preoperatively and at 1 week, and at 1 month, 3 months, and 6 months postoperatively, generating ET in central, paracentral, and midperipheral zones. The difference between postoperative and preoperative ET (ΔET) was computed for each zone. During follow-up, haze incidence and visual acuity were assessed and compared between groups.A total of 100 eyes completed all follow-up, including 40 eyes treated with MMC in MMC group and 60 eyes in control group without MMC treatment. For ΔET, between-group difference was found in midperipheral (P = .011) zone at 1 week postoperatively and in central (P = .036) and paracentral zones (P = .039) at 1 month postoperatively. Haze incidence was lower in MMC group at 1 week and 1 month postoperatively (P = .035 and .018, respectively). Safety index (postoperative uncorrected distance visual acuity/preoperative corrected distance visual acuity [CDVA]) and efficacy index (postoperative CDVA/preoperative CDVA) were higher in MMC group (P = .012 and P = .036, respectively) at 1 month postoperatively. No difference was found after 3 months postoperatively.With a temporary impact on corneal epithelial regeneration and refractive correction, intraoperative MMC application in transPRK decreased the haze incidence but had no effect on epithelial remodeling.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
张建发布了新的文献求助10
1秒前
Cloud关注了科研通微信公众号
3秒前
TKTK发布了新的文献求助10
3秒前
4秒前
Greta应助小熊维尼摇摇车采纳,获得10
5秒前
5秒前
斯文败类应助song采纳,获得10
6秒前
yun完成签到,获得积分20
8秒前
科研达人发布了新的文献求助10
8秒前
9秒前
xinyue946983发布了新的文献求助10
10秒前
Bailey发布了新的文献求助10
10秒前
CodeCraft应助CaoRouLi采纳,获得10
11秒前
慕青应助TKTK采纳,获得30
13秒前
Xiaojie完成签到,获得积分10
14秒前
15秒前
Ghost完成签到,获得积分10
15秒前
徐振阳发布了新的文献求助10
15秒前
17秒前
17秒前
独特元蝶发布了新的文献求助10
17秒前
19秒前
20秒前
21秒前
liangye2222发布了新的文献求助10
22秒前
22秒前
小毛驴完成签到,获得积分10
22秒前
23秒前
Huang_being发布了新的文献求助10
24秒前
refraincc发布了新的文献求助10
26秒前
song发布了新的文献求助10
28秒前
量子星尘发布了新的文献求助10
29秒前
Orange应助BeBrave1028采纳,获得10
29秒前
Andrew完成签到,获得积分10
29秒前
30秒前
独特元蝶完成签到,获得积分20
30秒前
醉熏的灵发布了新的文献求助30
30秒前
cyyyyyyyyyy完成签到,获得积分10
32秒前
何1发布了新的文献求助10
32秒前
yang完成签到,获得积分10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988975
求助须知:如何正确求助?哪些是违规求助? 3531316
关于积分的说明 11253424
捐赠科研通 3269917
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068