Effect of intraoperative mitomycin-C application on epithelial regeneration after transepithelial photorefractive keratectomy

医学 光折变性角膜切除术 丝裂霉素C 视力 眼科 外科 入射(几何) 前瞻性队列研究 眼病 光学 物理
作者
Nan‐Ji Lu,Carina Koppen,Shady T. Awwad,Minas I. Aslanides,Ioannis M. Aslanides,Shihao Chen
出处
期刊:Journal of Cataract and Refractive Surgery [Lippincott Williams & Wilkins]
卷期号:47 (2): 227-232 被引量:4
标识
DOI:10.1097/j.jcrs.0000000000000427
摘要

To investigate the effect of mitomycin-C (MMC) intraoperative application on postoperative corneal epithelial remodeling, haze incidence, and refractive correction in transepithelial photorefractive keratectomy (transPRK).Eye Hospital of Wenzhou Medical University, Wenzhou, China.Prospective randomized controlled study.Eyes that completed all follow-ups were included. Epithelial thickness (ET) map measurement was conducted preoperatively and at 1 week, and at 1 month, 3 months, and 6 months postoperatively, generating ET in central, paracentral, and midperipheral zones. The difference between postoperative and preoperative ET (ΔET) was computed for each zone. During follow-up, haze incidence and visual acuity were assessed and compared between groups.A total of 100 eyes completed all follow-up, including 40 eyes treated with MMC in MMC group and 60 eyes in control group without MMC treatment. For ΔET, between-group difference was found in midperipheral (P = .011) zone at 1 week postoperatively and in central (P = .036) and paracentral zones (P = .039) at 1 month postoperatively. Haze incidence was lower in MMC group at 1 week and 1 month postoperatively (P = .035 and .018, respectively). Safety index (postoperative uncorrected distance visual acuity/preoperative corrected distance visual acuity [CDVA]) and efficacy index (postoperative CDVA/preoperative CDVA) were higher in MMC group (P = .012 and P = .036, respectively) at 1 month postoperatively. No difference was found after 3 months postoperatively.With a temporary impact on corneal epithelial regeneration and refractive correction, intraoperative MMC application in transPRK decreased the haze incidence but had no effect on epithelial remodeling.
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