Comparison of the gut microbiota of short-term and long-term medical workers and non-medical controls: a cross-sectional analysis

维管菌 瘤胃球菌 梭菌目 微生物学 梭菌科 拟杆菌 微生物群 生物 阿克曼西亚 医学 链球菌 细菌 生物信息学 粪便 遗传学 毒素
作者
Ning Zheng,Shenghui Li,Bo Dong,Wen Sun,Huai-Rui Li,Yongli Zhang,Peng Li,Zhiwei Fang,Chang‐Ming Chen,Xiaoguang Han,Bo Li,Siyi Zhang,Meijuan Xu,Guixin Zhang,Yi Xin,Yufang Ma,Xianyao Wan,Qiulong Yan
出处
期刊:Clinical Microbiology and Infection [Elsevier BV]
卷期号:27 (9): 1285-1292 被引量:9
标识
DOI:10.1016/j.cmi.2020.10.033
摘要

The hospital environment has been implicated in the enrichment and exchange of pathogens and antibiotic resistance, but its potential in shaping the symbiotic microbial community of hospital staff is unclear. This study was designed to evaluate the alteration of the gut microbiome in medical workers compared to non-medical controls.A prospective cross-sectional cohort study was conducted in the intensive care unit (ICU) and other departments of a centre in north-eastern China. Faecal samples of 175 healthy medical workers-short-term (1-3 months) workers (n = 80) and long-term (>1 year) workers (n = 95)-and 80 healthy non-medical controls were analysed using 16S rRNA amplicon sequencing. The hospital environmental samples (n = 9) were also analysed.The gut microbiomes of medical workers exhibited marked deviations in diversity and alteration in microbial composition and function. Short-term workers showed significantly higher abundances of taxa such as Lactobacillus, Butyrivibrio, Clostridiaceae, Clostridium, Ruminococcus, Dialister, Bifidobacterium, Odoribacter, and Desulfovibrio and lower abundances of Bacteroides and Blautia than the controls. Long-term workers showed higher abundances of taxa such as Dialister, Veillonella, Clostridiaceae, Clostridium, Bilophila, Desulfovibrio, Pseudomonas, and Akkermansia and lower abundances of Bacteroides and Coprococcus than the controls. The medical workers' department (ICU versus non-ICU) and position (resident doctor versus nursing staff) also impacted their gut microbiome. Compared with the non-ICU workers, workers in the ICU showed a significant increase in the abundances of Dialister, Enterobacteriaceae, Phascolarctobacterium, Pseudomonas, Veillonella, and Streptococcus and a marked depletion of Faecalibacterium, Blautia, and Coprococcus. In contrast with the nursing staff, the resident doctors showed a significant increase in Erysipelotrichaceae and Clostridium and a decrease in Bacteroides, Blautia, and Ruminococcus in the gut microbiome. Moreover, we found that the microbiota of hospital environments potentially correlated with the workers' gut microbiota.Our findings demonstrated structural changes in the gut microbial community of medical workers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
背后海莲发布了新的文献求助10
刚刚
搞笑5次发布了新的文献求助10
1秒前
1秒前
2秒前
大模型应助zxmine采纳,获得30
2秒前
2秒前
哈哈哈哈哈完成签到,获得积分10
2秒前
3秒前
4秒前
犹豫大树发布了新的文献求助10
4秒前
Owen应助怕孤单的思雁采纳,获得10
4秒前
开塞露完成签到,获得积分10
4秒前
4秒前
大模型应助zeng采纳,获得10
4秒前
王玉河完成签到,获得积分20
5秒前
5秒前
DONGmumu发布了新的文献求助10
6秒前
yingqing完成签到,获得积分10
7秒前
肉松给肉松的求助进行了留言
7秒前
爆美完成签到,获得积分10
7秒前
8秒前
彭于晏应助尊敬雨双采纳,获得10
8秒前
9秒前
王玉河发布了新的文献求助10
9秒前
111发布了新的文献求助10
9秒前
领导范儿应助寒塘采纳,获得30
9秒前
cowboy123完成签到,获得积分10
9秒前
白茶完成签到,获得积分10
10秒前
桃子发布了新的文献求助10
10秒前
大模型应助1093465452zzz采纳,获得10
10秒前
11秒前
11秒前
12秒前
Tangyartie完成签到 ,获得积分10
13秒前
无奈的鞋子完成签到,获得积分10
13秒前
背后海莲完成签到,获得积分10
13秒前
笨笨乘风发布了新的文献求助10
14秒前
14秒前
YamDaamCaa给Mila的求助进行了留言
15秒前
小二郎应助Peng采纳,获得10
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970949
求助须知:如何正确求助?哪些是违规求助? 3515634
关于积分的说明 11179061
捐赠科研通 3250769
什么是DOI,文献DOI怎么找? 1795474
邀请新用户注册赠送积分活动 875831
科研通“疑难数据库(出版商)”最低求助积分说明 805188