CircRNA in female gestational and gynecological diseases

Circular RNA (circRNA) is a ubiquitous class of noncoding RNAs (ncRNAs) in all kingdoms of life with diverse structures.CircRNA is an endogenous noncoding RNA molecule with covalently close cyclic structure which does not have 5′ end cap and 3′ poly (A) tail. It is found to be evolutionary conservative and stable with tissue specificity. CircRNAs have many biological functions. In addition to acting as miRNA sponges, many other functions are being revealed, including regulator of gene transcription, and splicing and protein translation. It is involved in ovarian epithelial neoplasms, pre-eclampsia and other development. CircRNAs could regulate the expression of numerous gynecological cancer-related microRNA (miRNAs). The circRNA-miRNA-messenger RNA(mRNA) axis is a known regulatory pattern of several cancer-associated pathways, with both agonist and antagonist effects on carcinogenesis. Numerous studies have shown that circRNAs may become potential targets and clinical diagnostic markers for reproductive and gynecological diseases. This review focuses on the biogenesis and properties of circRNAs, databases of circRNA,their functions and potential significance in gestational, tumor and gestational diseases. Key words: RNA; Genital neoplasms, female; Pre-eclampsia; Biomarkers