医学
内科学
血管病学
无症状的
心脏病学
甘油三酯
钙化
逻辑回归
入射(几何)
冠状动脉粥样硬化
冠状动脉疾病
胆固醇
物理
光学
作者
Ki‐Bum Won,Eun Ji Park,Donghee Han,Ji Hyun Lee,Su‐Yeon Choi,Eun Ju Chun,Sung Hak Park,Hae Won Han,Jidong Sung,Hae Ok Jung,Hyuk‐Jae Chang
标识
DOI:10.1186/s12933-020-01008-5
摘要
Abstract Background Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults. Methods We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. Results During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100. Conclusion The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.
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