结晶
纳米晶
药物输送
材料科学
纳米技术
药品
化学工程
化学
有机化学
药理学
医学
工程类
作者
Yuan Gao,Jingkang Wang,Yongli Wang,Qiuxiang Yin,Brian Glennon,Jian Zhong,Jinbo Ouyang,Xin Huang,Hongxun Hao
标识
DOI:10.2174/1381612821666150531164350
摘要
Low water solubility of drug products causes delivery problems such as low bioavailability. The reduced particle size and increased surface area of nanocrystals lead to the increasing of the dissolution rate. The formulation of drug nanocrystals is a robust approach and has been widely applied to drug delivery system (DDS) due to the significant development of nanoscience and nanotechnology. It can be used to improve drug efficacy, provide targeted delivery and minimize side-effects. Crystallization is the main and efficient unit operation to produce nanocrystals. Both traditional crystallization methods such as reactive crystallization, anti-solvent crystallization and new crystallization methods such as supercritical fluid crystallization, high-gravity controlled precipitation can be used to produce nanocrystals. The current mini-review outlines the main crystallization methods addressed in literature. The advantages and disadvantages of each method were summarized and compared.
科研通智能强力驱动
Strongly Powered by AbleSci AI