光动力疗法
光毒性
内化
材料科学
生物物理学
纳米颗粒
体内
光子上转换
选择性
渗透(战争)
纳米技术
体外
细胞
化学
光电子学
生物化学
生物
催化作用
发光
有机化学
生物技术
工程类
运筹学
作者
Fangyuan Li,Yang Du,Jianan Liu,Heng Sun,Jin Wang,Ruiqing Li,Dokyoon Kim,Taeghwan Hyeon,Daishun Ling
标识
DOI:10.1002/adma.201802808
摘要
Abstract Upconversion nanoparticle (UCNP)‐mediated photodynamic therapy has shown great effectiveness in increasing the tissue‐penetration depth of light to combat deep‐seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor‐pH‐sensitive photodynamic nanoagents (PPNs) comprised of self‐assembled photosensitizers grafted pH‐responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self‐quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor‐cell internalization due to charge reversal but also are further disassembled into well‐dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP‐mediated deep‐tissue penetration of light and high therapeutic selectivity in vitro and in vivo.
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