前列腺切除术
手术切缘
前列腺癌
医学
腹腔镜前列腺根治术
前列腺
拉曼光谱
泌尿科
生物医学工程
癌症
内科学
光学
物理
作者
Michael Pinto,Kevin C. Zorn,Jacques P. Tremblay,Joannie Desroches,F. Dallaire,Kelly Aubertin,Eric Marple,Christopher Kent,Frédéric Leblond,Dominique Trudel,Frédéric Lesage
标识
DOI:10.1117/1.jbo.24.2.025001
摘要
Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures. Raman spectroscopy is a promising technology to assess surgical margins: its in vivo use during radical prostatectomy could help insure the extent of resected prostate and cancerous tissue is maximized. We thus present the design and development of a dual excitation Raman spectroscopy system (680- and 785-nm excitations) integrated to the robotic da Vinci surgical platform for in vivo use. Following validation in phantoms, spectroscopic data from 20 whole human prostates immediately following radical prostatectomy are obtained using the system. With this dataset, we are able to distinguish prostate from extra prostatic tissue with an accuracy, sensitivity, and specificity of 91%, 90.5%, and 96%, respectively. Finally, the integrated Raman spectroscopy system is used to collect preliminary spectroscopic data at the surgical margin in vivo in four patients.
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