内窥镜
光学
景深
图像分辨率
镜头(地质)
横截面
分辨率(逻辑)
材料科学
视野
光学(聚焦)
焦点深度(构造)
生物医学中的光声成像
生物医学工程
物理
计算机科学
解剖
地质学
外科
医学
人工智能
古生物学
构造学
俯冲
作者
Xiaowan Li,Kedi Xiong,Sihua Yang
摘要
Defocus scanning, which causes a serious deterioration of the transverse resolution out of the focal zone, is a big obstacle to the application of optical-resolution photoacoustic (PA) endoscopy (OR-PAE) in imaging internal hollow organs. However, the current solution to generate an adjustable focal length is inapplicable for in vivo imaging due to the greatly increased scanning time. In this study, by applying an elongated focus lens that produces Bessel beams to the OR-PAE, we developed a large-depth-of-field optical-resolution PA endoscope with a depth of focus of ∼8.6 mm in air, which can image targets at different depths without axial scanning, while maintaining a relatively constant transverse resolution. Ex vivo experimental results demonstrate the advantage of the endoscope to image biological tissues at different depths. Furthermore, an in vivo experiment presents three-dimensional vascular networks in the rabbit rectum, suggesting the potential of the endoscope for colorectal clinical applications.
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