利基
生物
干细胞
生殖系
干细胞巢
细胞生物学
果蝇属(亚属)
黑腹果蝇
生态位
体细胞
进化生物学
胚胎干细胞
果蝇科
遗传学
细胞命运测定
祖细胞
基因
生态学
栖息地
作者
Hwei-Jan Hsu,Majid Bahader,Chun-Ming Lai
标识
DOI:10.1007/s00018-019-03223-0
摘要
Adult stem cells have a unique capacity to renew themselves and generate differentiated cells that are needed in the body. These cells are recruited and maintained by the surrounding microenvironment, known as the stem cell niche, during organ development. Thus, the stem cell niche is required for proper tissue homeostasis, and its dysregulation is associated with tumorigenesis and tissue degeneration. The identification of niche components and the mechanisms that regulate niche establishment and maintenance, however, are just beginning to be uncovered. Germline stem cells (GSCs) of the Drosophila ovary provide an excellent model for studying the stem cell niche in vivo because of their well-characterized cell biology and the availability of genetic tools. In this review, we introduce the ovarian GSC niche, and the key signaling pathways for niche precursor segregation, niche specification, and niche extracellular environment establishment and niche maintenance that are involved in regulating niche size during development and adulthood.
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