医学
封锁
免疫系统
癌症研究
全身给药
免疫疗法
放射治疗
转移
免疫检查点
免疫学
癌症
药理学
体内
生物
内科学
受体
生物技术
作者
Yu Chao,Ligeng Xu,Chao Liang,Liangzhu Feng,Jun Xu,Ziliang Dong,Longlong Tian,Xuan Yi,Kai Yang,Zhuang Liu
标识
DOI:10.1038/s41551-018-0262-6
摘要
Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against hypoxic solid tumours and distant metastases. Here, we show that intratumoral injection, in mouse and rabbit xenografts and in patient-derived mouse xenografts, of a sodium alginate formulation containing catalase (Cat) labelled with the therapeutic 131I radioisotope enables long-term relief of tumour hypoxia and complete tumour elimination at low radioactivity doses. On injection, the soluble polysaccharide rapidly transforms into a hydrogel in the presence of endogenous Ca2+, fixing 131I-Cat within the tumours. We also show that local radiotherapy with a formulation that includes the immunostimulatory CpG oligonucleotide combined with systemic checkpoint-blockade therapy using an anti-CTLA-4 antibody leads to metastasis inhibition and protection against tumour rechallenge. The local therapy, which uses only biocompatible components, might enable new strategies for local tumour treatments that can be combined with systemic therapeutic responses, for the inhibition of tumour metastasis and the prevention of tumour recurrence in patients with advanced-stage cancer.
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