清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Development of a validated computer-based preoperative predictive model for pseudarthrosis with 91% accuracy in 336 adult spinal deformity patients

假关节 医学 接收机工作特性 脊柱侧凸 骨不连 矢状面 射线照相术 脊柱融合术 外科 畸形 后凸 放射科 内科学
作者
Justin K. Scheer,Tae-Min Oh,Justin S. Smith,Christopher I. Shaffrey,Alan H. Daniels,Daniel M. Sciubba,D. Kojo Hamilton,Themistocles S. Protopsaltis,Peter G. Passias,Robert A. Hart,Douglas C. Burton,Shay Bess,Renaud Lafage,Virginie Lafage,Frank J. Schwab,Eric O. Klineberg,Christopher P. Ames,_ _
出处
期刊:Neurosurgical Focus [American Association of Neurological Surgeons]
卷期号:45 (5): E11-E11 被引量:34
标识
DOI:10.3171/2018.8.focus18246
摘要

OBJECTIVE Pseudarthrosis can occur following adult spinal deformity (ASD) surgery and can lead to instrumentation failure, recurrent pain, and ultimately revision surgery. In addition, it is one of the most expensive complications of ASD surgery. Risk factors contributing to pseudarthrosis in ASD have been described; however, a preoperative model predicting the development of pseudarthrosis does not exist. The goal of this study was to create a preoperative predictive model for pseudarthrosis based on demographic, radiographic, and surgical factors. METHODS A retrospective review of a prospectively maintained, multicenter ASD database was conducted. Study inclusion criteria consisted of adult patients (age ≥ 18 years) with spinal deformity and surgery for the ASD. From among 82 variables assessed, 21 were used for model building after applying collinearity testing, redundancy, and univariable predictor importance ≥ 0.90. Variables included demographic data along with comorbidities, modifiable surgical variables, baseline coronal and sagittal radiographic parameters, and baseline scores for health-related quality of life measures. Patients groups were determined according to their Lenke radiographic fusion type at the 2-year follow-up: bilateral or unilateral fusion (union) or pseudarthrosis (nonunion). A decision tree was constructed, and internal validation was accomplished via bootstrapped training and testing data sets. Accuracy and the area under the receiver operating characteristic curve (AUC) were calculated to evaluate the model. RESULTS A total of 336 patients were included in the study (nonunion: 105, union: 231). The model was 91.3% accurate with an AUC of 0.94. From 82 initial variables, the top 21 covered a wide range of areas including preoperative alignment, comorbidities, patient demographics, and surgical use of graft material. CONCLUSIONS A model for predicting the development of pseudarthrosis at the 2-year follow-up was successfully created. This model is the first of its kind for complex predictive analytics in the development of pseudarthrosis for patients with ASD undergoing surgical correction and can aid in clinical decision-making for potential preventative strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wushuimei完成签到 ,获得积分10
4秒前
7秒前
如意2023完成签到 ,获得积分10
7秒前
孙老师完成签到 ,获得积分10
12秒前
Dmyb发布了新的文献求助10
14秒前
蝎子莱莱xth完成签到,获得积分10
29秒前
Dmyb完成签到,获得积分10
32秒前
氢锂钠钾铷铯钫完成签到,获得积分10
33秒前
恒牙完成签到 ,获得积分10
39秒前
Square完成签到,获得积分10
39秒前
49秒前
济民财完成签到,获得积分10
50秒前
mzhang2完成签到 ,获得积分10
56秒前
科研通AI2S应助雪山飞龙采纳,获得10
59秒前
葫芦芦芦完成签到 ,获得积分10
1分钟前
zyjsunye完成签到 ,获得积分0
1分钟前
雪山飞龙完成签到,获得积分10
1分钟前
MUAN完成签到 ,获得积分10
1分钟前
wjx完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
沉静香氛完成签到 ,获得积分10
1分钟前
CipherSage应助zzy682采纳,获得10
1分钟前
1分钟前
周娅敏完成签到,获得积分10
1分钟前
filter完成签到,获得积分10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
harden9159完成签到,获得积分10
1分钟前
1分钟前
zzy682发布了新的文献求助10
1分钟前
1分钟前
周娅敏发布了新的文献求助10
2分钟前
小苹果完成签到,获得积分20
2分钟前
英姑应助周娅敏采纳,获得10
2分钟前
晓薇完成签到,获得积分10
2分钟前
2分钟前
zzy682完成签到,获得积分10
2分钟前
mathmotive完成签到,获得积分20
2分钟前
量子星尘发布了新的文献求助10
2分钟前
zijingsy完成签到 ,获得积分10
2分钟前
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976713
求助须知:如何正确求助?哪些是违规求助? 3520805
关于积分的说明 11204819
捐赠科研通 3257584
什么是DOI,文献DOI怎么找? 1798771
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806648