Genotoxic Impurities in Pharmaceutical Manufacturing: Sources, Regulations, and Mitigation

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTGenotoxic Impurities in Pharmaceutical Manufacturing: Sources, Regulations, and MitigationGyorgy Szekely*†, Miriam C. Amores de Sousa‡, Marco Gil§, Frederico Castelo Ferreira*‡, and William Heggie*§View Author Information† School of Chemical Engineering & Analytical Science, The University of Manchester, The Mill, Sackville Street, Manchester M13 9PL, United Kingdom‡ Department of Bioengineering and Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001, Lisbon, Portugal§ Hovione FarmaCiencia SA, R&D, Sete Casas, 2674-506, Loures, Portugal*G.S. e-mail: [email protected]*F.C.F. e-mail: [email protected], [email protected]*W.H. e-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 16, 8182–8229Publication Date (Web):August 7, 2015Publication History Received7 March 2012Published online7 August 2015Published inissue 26 August 2015https://pubs.acs.org/doi/10.1021/cr300095fhttps://doi.org/10.1021/cr300095freview-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views8729Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Anions,Impurities,Organic compounds,Solvents Get e-Alerts