Tree ferns (Cyatheaceae) as a source of phenolic compounds – A review

Arborescent ferns of the genus Cyathea are often used in traditional medicine for the treatment of skin, kidney, and eye infections and even for degenerative diseases, such as cancer and diabetes. However, little is known about its compounds responsible for the medicinal properties attributed to this genus. Given the significant potential of these medicinal properties, the authors have performed a thorough literature review examining the potential of this genus as a source of bioactive molecules. Based on these findings, phenolic compounds have been identified as the most predominant bioactive component in this genus, which could be the molecules responsible for its therapeutic properties. Various studies, both in vivo and in vitro , have demonstrated the therapeutic properties of this genus, supporting its use in traditional medicine; thus, Cyathea could be a potential source of bioactive compounds. However, further studies are needed in order to identify the compounds present in this genus. • Cyathea tree ferns are used in traditional medicine. • Flavonoids are major phytochemicals found in Cyathea species. • Cyathea has been considered to be a potential source of novel cancer therapeutic compounds.