Nonenzymetic glucose sensitive device based on morchella shaped nickel-copper layered double hydroxide

A nonenzymetic electrochemical glucose sensitive device has been prepared by assembling sensitive electrode with polydimethylsiloxane (PDMS). The sensitive electrode was prepared based on morchella shaped nickel-copper layered double hydroxide (Ni-Cu LDH) which was prepared by decorating Ni-Cu LDH on the Cu(OH) 2 nanowires and supported on Cu foam (Ni-Cu LDH@Cu(OH) 2 NWs/CuF). The as-developed device exhibits outstanding electrocatalytic performance toward glucose, including high sensitivity (7.08 μA/μM/cm 2 ), large linear interval and long-term stability. • The Ni-Cu LDH@Cu(OH) 2 NWs core-shell nanocomposites were synthesized on Cu foam. • The feeding mole ratio of Ni and Cu was investigated and optimized. • The Ni-Cu LDH@Cu(OH) 2 NWs/CuF was integrated with PDMS to develop sensitive device. • The sensitive device exhibits high sensitivity and outstanding long-term stability. We present a kind of three-dimensional core-shell hierarchical structure based on nickel-copper layered double hydroxide (Ni-Cu LDH), in which the morchella shaped Ni-Cu LDH shells were synthesized on the nanowire-shaped Cu(OH) 2 backbones and grown on Cu foam (CuF) substrate (Ni-Cu LDH@Cu(OH) 2 NWs/CuF). The as-fabricated nanocomposites were characterized and used for nonenzymetic glucose determination. The sensing properties of Ni-Cu LDH@Cu(OH) 2 NWs/CuF were optimized by changing the mole ratio of Ni and Cu, demonstrating the optimized electrode (Ni:Cu = 4:2) has remarkable response/recovery times (1.5/3.5 s towards 200 μM glucose), fine reproducibility and anti-interference properties, as well as anti-bending performance. Furthermore, the as-prepared optimized electrode was used to develop sensitive device by assembling with counter and reference electrodes into polydimethylsiloxane (PDMS)-based micro-cavity. The sensitive device exhibits a high sensitivity of 7.08 μA/μM/cm 2 , a good linear range of 0.006–1.6 μM, and a detection boundary of 1.3 μM. In addition, the developed device demonstrates good stability and can achieve the determination of glucose in human serum. Therefore, the morchella shaped Ni-Cu LDH hierarchical structures has shown an outstanding performance and can be used for detecting glucose level in serum samples, so it represents a promising sensitive material for constructing enzymeless glucose sensor.