Epicutaneous application of Imiquimod to model psoriasis-like skin disease induces water-saving aestivation motifs and vascular inflammation

The chronic inflammatory skin-disease psoriasis is associated with cardiovascular disease leading to a reduced life expectancy.(Mehta et al., 2010) This makes strategies to improve cardiovascular risk management in psoriasis patients essential(Garshick and Berger, 2022), for which better understanding of the skin-vasculature crosstalk lays the foundation.