生物相容性材料
表面改性
共价键
对比度(视觉)
材料科学
化学
化学工程
纳米技术
生物医学工程
物理化学
计算机科学
有机化学
工程类
人工智能
作者
Viktorie Neubertová,Olga Guselnikova,Yusuke Yamauchi,Anastasia Olshtrem,Silvie Rimpelová,Erik Čižmár,M. Orendáč,Jan Duchoň,Lenka Volfová,J. Lančok,Vı́t Herynek,Přemysl Fitl,Pavel Ulbrich,Luděk Jelínek,Patrik Schneider,Juraj Košek,Павел С. Постников,Zdeňka Kolská,Václav Švorčı́k,Sergii Chertopalov
标识
DOI:10.1016/j.cej.2022.136939
摘要
• The covalent functionalization of MXene with diethylenetriaminepentaacetic acid was proposed. • MXene-DTPA complexing with Gd 3+ provided paramagnetic response to the diamagnetic MXene. • MXene-Gd showed T 1 -MR imaging activity. • MXene-Gd showed oxidative resistance in phosphate buffer saline and blood serum. • The chelation of Gd 3+ ions by MXene-DTPA prevented leaking to bioliquids. MXenes are an excellent candidate for medical applications, including diagnostic approaches such as positron emission tomography, computed tomography, and magnetic resonance imaging (MRI). However, the utilization of MXenes for bioimaging is restricted by their commonly diamagnetic nature. MXenes can be functionalized using ferromagnetic or paramagnetic compounds and nanoparticles to develop efficient bioimaging tools. In contrast to previously published approaches based on electrostatic interactions, covalent approaches could enhance MXene stability and prevent self-aggregation with degradation. This work proposes covalent functionalization of Ti 3 C 2 T flakes with a chelating agent diethylenetriaminepentaacetic acid (DTPA) and further complexing with Gd 3+ ions. The developed functionalization procedure provides a paramagnetic response to the intrinsically diamagnetic Ti 3 C 2 T flakes for T 1 -MR imaging. Moreover, we observed the apparent dependency of magnetic relaxation time on the flake concentration, which enabled us to estimate the spatially resolved flake distribution. The covalent decoration strategy for MXene led to surface protection against oxidation in phosphate buffer saline and blood serum, accompanied by increased cytocompatibility. Moreover, chelation of Gd 3+ ions prevented leaking compared with electrostatic chemisorption. We demonstrated a high degree of photothermal conversion efficiency of MXene-Gd, anticipating future application in photothermal therapy. This work broadens the bioapplication of MXenes, not only by introducing an MRI contrast but also by developing covalent functionalization strategies for MXenes.
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