Insights from hydrogenase model studies on C–C bond forming reactions

In this review, we discuss whether the ligand design used in catalysts mimicking O2-tolerant [NiFe]hydrogenase ([NiFe]H2ase) can be applied to ligand design in catalysts for C–C bond forming reactions. First, we begin with a discussion of ligand design in catalysts that allow reductive activation of O2 by H2, using an O2-tolerant [NiFe]H2ase model catalyst. Next, we discuss whether this ligand design methodology can be applied to reductive C–C coupling and C–H arylation reactions. Finally, we summarize the ligand design in the catalysts for reductive C–C coupling and C–H arylation reactions.