根茎
姜科
化学
姜黄
生物测定
立体化学
细胞毒性
传统医学
生物
生物化学
体外
医学
遗传学
作者
Mohammad Al‐Amin,Nagla Mustafa Eltayeb,Chowdhury Faiz Hossain,Siti Sarah Fazalul Rahiman,Melati Khairuddean,Salizawati Muhamad Salhimi
标识
DOI:10.1080/10286020.2022.2081562
摘要
Bioassay-guided separation afforded furanodienone 1,10-epoxide (9) as the new compound, curcolone (10) as partially described compound and ten known compounds; germacrone (1), furanodienone (2), curzerenone (3), curcumenol (4), zederone (5), comosone II (6), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (7), 13-hydroxygermacrone (8), curcuzederone (11) and demethoxycurcumin (12). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of C. aeruginosa rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of C. aeruginosa rhizomes.
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