肌张力障碍
医学
巴氯芬
麻醉
痉挛
外科
大池
苍白球切开术
内科学
脑脊液
精神科
受体
脑深部刺激
兴奋剂
疾病
帕金森病
作者
Jianni Wu,Barry Ceverha,Bi‐Ying Yeh,Kimberly K. BeDell
出处
期刊:Journal of pediatric rehabilitation medicine
[IOS Press]
日期:2022-03-29
卷期号:15 (1): 145-150
摘要
The aim of the study was to evaluate the use of a novel technique for baclofen delivery using an intrathecal catheter inserted through a lumbar laminotomy with the tip placed at the cisterna magna (supraspinal baclofen (SSB)) for the treatment of severe generalized secondary dystonia.A cohort study of six individuals (4M/2F, mean±SD = 15±4.86 years) with generalized dystonia unresponsive to oral medications were treated with SSB and followed clinically for 9 years. Intrathecal catheter tips were positioned under fluoroscopic guidance just above the level of the foramen magnum, at the cisterna magna.Five of the 6 patients experienced sustained benefit with SSB; the group mean modified Fahn-Marsden scale scores decreased from 95 to 55 (t = 3.29, p = 0.02). One patient suffered complex pump pocket infection, and therefore underwent pump explantation.Supraspinal baclofen may be an effective method for infusing baclofen into the ventricular system of the brain for treatment of secondary dystonia which is unresponsive to oral therapy.
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