The antibacterial property of zinc oxide/graphene oxide modified porous polyetheretherketone against S. sanguinis, F. nucleatum and P. gingivalis

Abstract About 30% failures of implant are caused by peri-implantitis. Subgingival plaque, consisting of S. sanguinis, F. nucleatum, P. gingivalis et al , is the initiating factor of peri-implantitis. Polyetheretherketone (PEEK) is widely used for the fabrication of implant abutment, healing cap and temporary abutment in dental applications. As a biologically inert material, PEEK has shown poor antibacterial properties. To promote the antibacterial activity of PEEK, we loaded ZnO/GO on sulfonated PEEK. We screened out that when mass ratio of ZnO/GO was 4:1, dip-coating time was 25 min, ZnO/GO modified SPEEK shown the best physical and chemical properties. At the meantime, the ZnO/GO-SPEEK samples possess a good biocompatibility. The ZnO/GO-SPEEK inhibits P. gingivalis obviously, and could exert an antibacterial activity to S. sanguinis in the early stage, prevents biofilm formation effectively. With the favorable in vitro performances, the modification of PEEK with ZnO/GO is promising for preventing peri-implantitis.