生物分子
石墨烯
电极
纳米技术
材料科学
检出限
分析物
纳米尺度
纳米结构
生物传感器
光电子学
化学
物理化学
色谱法
作者
Md. Azahar Ali,Chunshan Hu,Bin Yuan,Sanjida Jahan,Mohammad Sadeq Saleh,Zhitao Guo,Andrew J. Gellman,Rahul Panat
标识
DOI:10.1038/s41467-021-27361-x
摘要
Sensing of clinically relevant biomolecules such as neurotransmitters at low concentrations can enable an early detection and treatment of a range of diseases. Several nanostructures are being explored by researchers to detect biomolecules at sensitivities beyond the picomolar range. It is recognized, however, that nanostructuring of surfaces alone is not sufficient to enhance sensor sensitivities down to the femtomolar level. In this paper, we break this barrier/limit by introducing a sensing platform that uses a multi-length-scale electrode architecture consisting of 3D printed silver micropillars decorated with graphene nanoflakes and use it to demonstrate the detection of dopamine at a limit-of-detection of 500 attomoles. The graphene provides a high surface area at nanoscale, while micropillar array accelerates the interaction of diffusing analyte molecules with the electrode at low concentrations. The hierarchical electrode architecture introduced in this work opens the possibility of detecting biomolecules at ultralow concentrations.
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