阿尔戈瑙特
生物
古细菌
核酸
基因组
计算生物学
核糖核酸
遗传学
基因
RNA干扰
作者
Jorrit W. Hegge,Daan C. Swarts,John van der Oost
标识
DOI:10.1038/nrmicro.2017.73
摘要
Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
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