类风湿性关节炎
基因敲除
关节炎
医学
核糖核酸
信使核糖核酸
免疫系统
调节器
发病机制
小RNA
免疫学
基因
生物
遗传学
作者
Lin‐Chong Su,An‐Fang Huang,Hong Jia,Yi Liu,Wang‐Dong Xu
标识
DOI:10.1111/1756-185x.13202
摘要
Abstract Micro RNA s (mi RNA s) are a recently discovered class of post‐transcriptional regulators that induce target messenger RNA degradation or translation inhibition. mi RNA ‐155 (miR‐155) is an important regulator of immune cells both in humans and mice, by which these cells play critical roles in the pathogenesis of rheumatoid arthritis ( RA ). Recent findings showed that expression of miR‐155 was elevated in RA patients and arthritis models. Moreover, miR‐155 overexpression or knockdown performed significantly in the development of arthritis. This review summarizes the recent findings with respect to miR‐155 in immune responses and the underlying mechanisms responsible for miR‐155‐related autoimmune arthritis. Hopefully the information obtained will benefit the development of novel therapeutic strategies.
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