对映选择合成
立体中心
烯烃
位阻效应
钯
反应性(心理学)
化学
手性配体
催化作用
配体(生物化学)
立体化学
组合化学
有机化学
受体
生物化学
病理
医学
替代医学
作者
Naifu Hu,Ke Li,Zheng Wang,Wenjun Tang
标识
DOI:10.1002/anie.201600379
摘要
Abstract A highly enantioselective alkene aryloxyarylation led to the high‐yielding formation of a series of 1,4‐benzodioxanes, 1,4‐benzooxazines, and chromans containing quaternary stereocenters with excellent enantioselectivity. The sterically bulky and conformationally well defined chiral monophosphorus ligand L4 or L5 was responsible for the high reactivity and enantioselectivity of these transformations. The application of this method to the synthesis of the chiral chroman backbone of α‐tocopherol was demonstrated.
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